- ºÐ¼®ÈÇаú ±â±âºÐ¼®¿¡ ´ëÇÑ Àü¹ÝÀûÀÎ Àü°ø Áö½ÄÀ» ´ã¾Ò½À´Ï´Ù.
- ºÐ¼®¿¡¼ »ç¿ë µÇ´Â ±âº»ÀûÀÎ ¿ë¾î¿Í ºÐ¼® °úÁ¤¿¡ ´ëÇÑ °³³äÀ» ¹è¿ï ¼ö ÀÖ½À´Ï´Ù.
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ÆÇ±Ç ÆäÀÌÁö
±â±â ºÐ¼® À̶õ?
summary 1
ºÐ¼®ÈÇаú ±â±âºÐ¼®
ºÐ¼® °úÁ¤°ú ¿ë¾îµé
Random error¿Í Systematic error
Æò±Õ°ú Ç¥ÁØÆíÂ÷
Á¤±ÔºÐÆ÷ (Normal Distribution)
¿ÀÂ÷ °£ÀÇ °è»ê
Standard deviation of the mean
µ¥ÀÌÅÍÀÇ Åë°è ºÐ¼® #1
summary2
½Å·Ú ±¸°£°ú TºÐÆ÷
°ËÁ¤À̶õ?
T°ËÁ¤- One and two sample t-test
T°ËÁ¤- paired sample t-test
F-°ËÁ¤
ÀÌ»óÄ¡ (Outlier)ÀÇ È®ÀÎ
ÀÌ»óÄ¡ (Outlier)ÀÇ Á¦°Å
ºÐ»ê ºÐ¼® (Analysis of Variances, ANOVA)
p value
ºñ¸ð¼ö °ËÁ¤¹ý
ºñ¸ð¼ö ºÐ»êºÐ¼®¹ý
»çÈÄ °ËÁ¤ (Post-Hoc test)
µ¥ÀÌÅÍÀÇ Åë°è ºÐ¼® #2
summary 3
Linear regression analysis (¼±Çü ȸ±Í ºÐ¼®)
Correlation coefficient¿Í residual plot
Method validation°ú Á¤È®µµ(Accuracy)ÀÇ È®ÀÎ
Á¤¹Ðµµ(Precision)ÀÇ È®ÀÎ
Á¤¼ºÇÑ°è¿Í Á¤·®ÇÑ°è
Linear regression in Excel
Sensitivity and Selectivity
ºÐ¸®ÀÌ·Ð #1
summary 4
ÈÇÐÀû ºÐ¸® (Chemical separation)
̧̉ (Extraction)
Partition coefficient
Distribution coefficient with acid
Distribution coefficient with base
¹Ýº¹ ÃßÃâ (Multi step extraction)
Counter current extraction
ºÐ¸®ÀÌ·Ð #2
summary 5
Å©·Î¸¶Åä±×·¡ÇÇ (Chromatography)
ÀÌ·Ð ´Ü¼ö (Theoretical plates)
Van Deemter equation
Column parameters
ÃÊÀÓ°è À¯Ã¼
Soxhlet extraction
Cocurrent vs Counter current flow
Ionic liquids
°¡½ºÅ©·Î¸¶Åä±×·¡ÇÇ (GC)
summary 6
Gas Chromatography Ư¡
Retention time °áÁ¤ ÀÎÀÚµé
°¡½ºÅ©·Î¸¶Åä±×·¡ÇÇÀÇ À̵¿»ó
GC Ä÷³
GC °ËÃâ±â (TCD & FID)
´Ù¸¥ Á¾·ù detector
Kovat¡¯s number
Bleeding
Detector: Mass spectrometry
Solid phase microextraction (SPME)
Sample Injection and Pretreatment
Sample injection mode
¾×üũ·Î¸¶Åä±×·¡ÇÇ (LC) #1
summary 7
HPLC ÀϹÝ
LC column particles
HPLC detector- UV
HPLC detector- RI & ELSD
HPLC detector- Electrochemical °ËÃâ±â & fluorescence °ËÃâ±â
Liquid Chromatography-Mass Spectrometry (LC-MS)
Sample derivatization
Suppressed ion chromatography
´Ù¾çÇÑ HPLC
¾×üũ·Î¸¶Åä±×·¡ÇÇ (LC) #2
summary 8
LC technique 1- Adsorption
LC technique 2- Partition I- Reverse phase
LC technique 2- Partition II- Solvents
LC technique 2- Partition III-column
LC technique 3- Ion-exchange I
Ion-paring chromatography
LC technique 4- Size-exclusion
LC technique 5- Affinity chromatography
Àü±â ¿µµ¿
summary 9
Electrophoresis (Àü±â¿µµ¿)
Electrophoretic mobility & electroosmosis
Band broadening factors
Gel electrophoresis
Isoelectric focusing & 2-Dimensional gel
Capillary electrophoresis
Capillary electrophoresis techiniques
Mass spectroscopy with gels
Gel mobility shift assay
Capillary electrophoresis with chip
Capillary electrophoresis for DNA sequencing