In Part 2, White Fang experiences his first contact with human society and the development of complex relationships with humans. Initially captured by humans, White Fang passes through the hands of various owners, enduring much abuse and suffering. However, he eventually meets a master who provides genuine affection and care. This part focuses on the psychological and emotional changes and growth White Fang undergoes as he adapts to the human world, ultimately finding stability with a loving owner, referred to as 'the love-master.' During this process, White Fang also experiences conflicts between his instincts and loyalty, coming to understand the meanings of love and loyalty.

Chapter I. The Makers of Fire
Chapter II. The Bondage
Chapter III. The Outcast
Chapter IV. The Trail of the Gods
Chapter V. The Covenant
Chapter VI. The Famine
Chapter VII. The Enemy of His Kind
Chapter VIII. The Mad God
Chapter IX. The Reign of Hate
Chapter X. The Clinging Death
Chapter XI. The Indomitable
Chapter XII. The Love-Master
Chapter XIII. The Long Trail
Chapter XIV. The Southland
Chapter XV. The God’s Domain
Chapter XVI. The Call of Kind
Chapter XVII. The Sleeping Wolf