The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global
public health issue with an increase in mortality and morbidity. Here we report
our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed
(ligand-free) and open (ligand-bound) conformation, which is involved in host cell
adhesion. We also predict the unique N- and O-linked glycosylation sites of spike
glycoprotein that distinguish it from the SARS and underlines shielding and
camouflage of COVID-19 from the host the defence system. Furthermore, our
study also highlights the key finding that the S1 domain of COVID-19 spike
glycoprotein potentially interacts with the human CD26, a key immunoregulatory
factor for hijacking and virulence. These findings accentuate the unique features of
COVID-19 and assist in the development of new therapeutics.
등록상표
Emerging Microbes

제 1편 코로나바이러스 정의
1. 코로나바이러스감염증-19(Covid-19) 정보 7
2. 코로나바이러스 분류 및 특성 9
3. 코로나바이러스 전자현미경 형태 11
4. 코로나바이러스 구조 (Covid-19 Organization) 13
5. 코로나19: 환경에 지속적인 영향을 미칠까? 19
6. 치료법(Therapeutical Method) 22

제 2편 연구논문
Emerging WuHan (COVID-19) coronavirus: glycan shield and structure
prediction of spike glycoprotein and its interaction with human CD26

1. Abstract 23
2. Introduction 23
3. Acknowledgements 26
4. Disclosure statement 26
5. References 26